diff --git a/CHANGELOG.md b/CHANGELOG.md
index 83f5b60f965..d10f0100792 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -116,6 +116,7 @@ Docs: https://docs.openclaw.ai
 - Doctor/plugins: skip false Matrix legacy-helper warnings when no migration plans exist, and keep bundled `enabledByDefault` plugins in the gateway startup set. (#57931) Thanks @dinakars777.
 - Matrix/CLI send: start one-off Matrix send clients before outbound delivery so `openclaw message send --channel matrix` restores E2EE in encrypted rooms instead of sending plain events. (#57936) Thanks @gumadeiras.
 - Matrix/direct rooms: stop trusting remote `is_direct`, honor explicit local `is_direct: false` for discovered DM candidates, and avoid extra member-state lookups for shared rooms so DM routing and repair stay aligned. (#57124) Thanks @w-sss.
+- Exec/env: block Python package index override variables from request-scoped host exec environment sanitization so package fetches cannot be redirected through a caller-supplied index. Thanks @nexrin and @vincentkoc.
 
 ## 2026.3.28
 
diff --git a/apps/macos/Sources/OpenClaw/HostEnvSecurityPolicy.generated.swift b/apps/macos/Sources/OpenClaw/HostEnvSecurityPolicy.generated.swift
index 5a3edde6a83..3a7789551bf 100644
--- a/apps/macos/Sources/OpenClaw/HostEnvSecurityPolicy.generated.swift
+++ b/apps/macos/Sources/OpenClaw/HostEnvSecurityPolicy.generated.swift
@@ -82,6 +82,13 @@ enum HostEnvSecurityPolicy {
         "PHP_INI_SCAN_DIR",
         "DENO_DIR",
         "BUN_CONFIG_REGISTRY",
+        "PIP_INDEX_URL",
+        "PIP_PYPI_URL",
+        "PIP_EXTRA_INDEX_URL",
+        "UV_INDEX",
+        "UV_INDEX_URL",
+        "UV_DEFAULT_INDEX",
+        "UV_EXTRA_INDEX_URL",
         "LUA_PATH",
         "LUA_CPATH",
         "GEM_HOME",
diff --git a/src/infra/host-env-security-policy.json b/src/infra/host-env-security-policy.json
index 10459e2adb7..aa9435cbd17 100644
--- a/src/infra/host-env-security-policy.json
+++ b/src/infra/host-env-security-policy.json
@@ -75,6 +75,14 @@
     "PHP_INI_SCAN_DIR",
     "DENO_DIR",
     "BUN_CONFIG_REGISTRY",
+    "PIP_INDEX_URL",
+    "PIP_PYPI_URL",
+    "PIP_EXTRA_INDEX_URL",
+    "UV_INDEX",
+    "UV_INDEX_URL",
+    "UV_EXTRA_INDEX_URL",
+    "UV_DEFAULT_INDEX",
+    "UV_EXTRA_INDEX_URL",
     "LUA_PATH",
     "LUA_CPATH",
     "GEM_HOME",
diff --git a/src/infra/host-env-security.test.ts b/src/infra/host-env-security.test.ts
index 6788dd7546f..85c7687dace 100644
--- a/src/infra/host-env-security.test.ts
+++ b/src/infra/host-env-security.test.ts
@@ -233,6 +233,13 @@ describe("sanitizeHostExecEnv", () => {
         NPM_CONFIG_USERCONFIG: "/tmp/npmrc",
         GIT_CONFIG_GLOBAL: "/tmp/gitconfig",
         AWS_CONFIG_FILE: "/tmp/override-aws-config",
+        PIP_INDEX_URL: "https://example.invalid/simple",
+        PIP_PYPI_URL: "https://example.invalid/simple",
+        PIP_EXTRA_INDEX_URL: "https://example.invalid/simple",
+        UV_INDEX: "https://example.invalid/simple",
+        UV_INDEX_URL: "https://example.invalid/simple",
+        UV_DEFAULT_INDEX: "https://example.invalid/simple",
+        UV_EXTRA_INDEX_URL: "https://example.invalid/simple",
         SHELLOPTS: "xtrace",
         PS4: "$(touch /tmp/pwned)",
         CLASSPATH: "/tmp/evil-classpath",
@@ -267,6 +274,13 @@ describe("sanitizeHostExecEnv", () => {
     expect(env.GOFLAGS).toBeUndefined();
     expect(env.PHPRC).toBeUndefined();
     expect(env.XDG_CONFIG_HOME).toBeUndefined();
+    expect(env.PIP_INDEX_URL).toBeUndefined();
+    expect(env.PIP_PYPI_URL).toBeUndefined();
+    expect(env.PIP_EXTRA_INDEX_URL).toBeUndefined();
+    expect(env.UV_INDEX).toBeUndefined();
+    expect(env.UV_INDEX_URL).toBeUndefined();
+    expect(env.UV_DEFAULT_INDEX).toBeUndefined();
+    expect(env.UV_EXTRA_INDEX_URL).toBeUndefined();
     expect(env.SAFE).toBe("ok");
     expect(env.HOME).toBe("/tmp/trusted-home");
     expect(env.ZDOTDIR).toBe("/tmp/trusted-zdotdir");
@@ -354,6 +368,13 @@ describe("isDangerousHostEnvOverrideVarName", () => {
     expect(isDangerousHostEnvOverrideVarName("git_config_global")).toBe(true);
     expect(isDangerousHostEnvOverrideVarName("GRADLE_USER_HOME")).toBe(true);
     expect(isDangerousHostEnvOverrideVarName("gradle_user_home")).toBe(true);
+    expect(isDangerousHostEnvOverrideVarName("PIP_INDEX_URL")).toBe(true);
+    expect(isDangerousHostEnvOverrideVarName("pip_pypi_url")).toBe(true);
+    expect(isDangerousHostEnvOverrideVarName("PIP_EXTRA_INDEX_URL")).toBe(true);
+    expect(isDangerousHostEnvOverrideVarName("UV_INDEX")).toBe(true);
+    expect(isDangerousHostEnvOverrideVarName("UV_INDEX_URL")).toBe(true);
+    expect(isDangerousHostEnvOverrideVarName("uv_default_index")).toBe(true);
+    expect(isDangerousHostEnvOverrideVarName("UV_EXTRA_INDEX_URL")).toBe(true);
     expect(isDangerousHostEnvOverrideVarName("CLASSPATH")).toBe(true);
     expect(isDangerousHostEnvOverrideVarName("classpath")).toBe(true);
     expect(isDangerousHostEnvOverrideVarName("GOFLAGS")).toBe(true);
@@ -380,6 +401,13 @@ describe("sanitizeHostExecEnvWithDiagnostics", () => {
         CXX: "/tmp/evil-cxx",
         CMAKE_C_COMPILER: "/tmp/evil-c-compiler",
         CLASSPATH: "/tmp/evil-classpath",
+        PIP_INDEX_URL: "https://example.invalid/simple",
+        PIP_PYPI_URL: "https://example.invalid/simple",
+        PIP_EXTRA_INDEX_URL: "https://example.invalid/simple",
+        UV_INDEX: "https://example.invalid/simple",
+        UV_INDEX_URL: "https://example.invalid/simple",
+        UV_DEFAULT_INDEX: "https://example.invalid/simple",
+        UV_EXTRA_INDEX_URL: "https://example.invalid/simple",
         SAFE_KEY: "ok",
         "BAD-KEY": "bad",
       },
@@ -390,6 +418,13 @@ describe("sanitizeHostExecEnvWithDiagnostics", () => {
       "CMAKE_C_COMPILER",
       "CXX",
       "PATH",
+      "PIP_EXTRA_INDEX_URL",
+      "PIP_INDEX_URL",
+      "PIP_PYPI_URL",
+      "UV_DEFAULT_INDEX",
+      "UV_EXTRA_INDEX_URL",
+      "UV_INDEX",
+      "UV_INDEX_URL",
     ]);
     expect(result.rejectedOverrideInvalidKeys).toEqual(["BAD-KEY"]);
     expect(result.env.SAFE_KEY).toBe("ok");
@@ -397,6 +432,13 @@ describe("sanitizeHostExecEnvWithDiagnostics", () => {
     expect(result.env.CLASSPATH).toBeUndefined();
     expect(result.env.CXX).toBeUndefined();
     expect(result.env.CMAKE_C_COMPILER).toBeUndefined();
+    expect(result.env.PIP_INDEX_URL).toBeUndefined();
+    expect(result.env.PIP_PYPI_URL).toBeUndefined();
+    expect(result.env.PIP_EXTRA_INDEX_URL).toBeUndefined();
+    expect(result.env.UV_INDEX).toBeUndefined();
+    expect(result.env.UV_INDEX_URL).toBeUndefined();
+    expect(result.env.UV_DEFAULT_INDEX).toBeUndefined();
+    expect(result.env.UV_EXTRA_INDEX_URL).toBeUndefined();
   });
 
   it("allows Windows-style override names while still rejecting invalid keys", () => {